MDITI traces its roots to ancient medical history. As one of the cardinal signs of pathology, Hippocrates said, "In whatever part of the body excesses of heat or cold is felt, the disease is there to be discovered".

Ancient Greek physicians used a primitive form of thermology. By applying a thin mud mixture on areas of a patient's body and observing the mud's patterns and rates of drying, they were able to ascertain problem or disease areas. Aside from the Greek, ancient and modern Chinese and Ayurvedic medicine often employ body heat as a diagnostic tool.

In modern times, application of thermography was utilized for military purposes. This led to the development of the first electronic infrared sensors. After many years of development and proven usefulness, infrared technology passed to other industries and fields. Warmly accepted by the industrial world, thermography further developed its unique uses in different fields. In medicine, early medical thermographers had to use industrial infrared cameras. Decades passed before medically dedicated thermographic cameras were developed.

The pioneers of thermography were experts in fields of breast oncology, vascular medicine or neurology who worked in multi-modal diagnostic specialty centers and observed that thermograms of women with malignant breast tumors characteristically showed abnormal and high-energy blood vessels near the tumor. In 1971, these abnormal blood vessels were understood, when Dr. Judah Folkman formalized the theory of neo-angiogenesis.